Guo huai wife sexual dysfunction

Guo huai wife sexual dysfunction

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Jia Nanfeng

Erectile dysfunction ED associated with type 2 diabetes is a severe problem that requires effective treatment. Pancreatic kininogenase PK has the potential to improve the erectile function of ED patients. This study aims to investigate the effect of PK on erectile function in streptozotocin-induced type 2 diabetic ED rats. To achieve this goal, we divided male Sprague—Dawley rats into five groups. One group was not treated, and the other four groups were treated with saline, sildenafil, PK or sildenafil, and PK, respectively, Guo huai wife sexual dysfunction 4 weeks after the induction of type 2 diabetic ED.

Then, intracavernous pressure under cavernous nerve stimulation was measured, and penile tissue was collected for further study.

Endothelial nitric oxide synthase levels, smooth muscle content, Guo huai wife sexual dysfunction content, cyclic guanosine monophosphate cGMP levels in the corpus cavernosum, and neuronal nitric oxide synthase levels in the dorsal penile nerve were measured.

Improved erectile function and endothelium and smooth muscle content in the corpus cavernosum were observed in diabetic ED rats.

When treating diabetic ED rats "Guo huai wife sexual dysfunction" PK and sildenafil at the same time, a better therapeutic effect was achieved. These data demonstrate that intraperitoneal injection of PK can improve erectile function in a rat model of type 2 diabetic ED. With further research on specific mechanisms of erectile function improvement, PK may become a novel treatment for diabetic ED.

Pancreatic kininogenase PK has been reported to be the main treatment for diabetic nephropathy. PK, a tissue kallikrein extracted from pig pancreas, can convert kininogen into bradykinin and kallidin-like peptide in rodents or kallidin in humans.

The diabetic condition impairs the endothelium and smooth muscle in corpus cavernosum, which are fundamental for normal erections. However, it remains unknown whether PK has the same effect on corpus cavernosum as on the kidney. In the present study, we investigated the effect of PK on the erectile function of streptozotocin-induced type 2 diabetic ED rats.

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